L4762
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L4762
Sigma
Loperamide hydrochloride
| Synonym: | 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride |
| CAS Number: | 34552-83-5 |
| Linear Formula: | C29H33ClN2O2 · HCl |
| Molecular Weight: | 513.50 |
| EC Number: | 252-082-4 |
| MDL number: | MFCD00058581 |
| PubChem Substance ID: | 24278042 |
Description
| Biochem/physiol Actions | Non-selective Ca2+ channel blocker. At nanomolar concentrations, binds to μ opioid receptors; does not cross blood brain barrier. |
Properties
| Gene Information | human ... OPRM1(4988) |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TM4960000 |
References
| reference | Liu, I.M., et al., Activation of opioid μ-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats. Neurosci. Lett. 265, 183-186, (1999) Abstract |
| DeHaven-Hudkins, Loperamide (ADL 2-1294) an opioid antihyperalgesic agent with peripheral selectivity. J. Pharmacol. Exp. Ther. 289, 494, (1999) Abstract | |
| Church, J., et al., Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol. Pharmacol. 45, 747-757, (1994) Abstract | |
| Daly, J.W., Harper, J., Loperamide: novel effects on capacitative calcium influx. Cell. Mol. Life Sci. 57, 149, (2000) Abstract |
